UAMS Investigators: Gohar Azhar, M.D., professor, Department of Geriatrics; director of Clinical Research, director of the Pat Walker Memory Clinic and Research Center, and co-director of the Cardiovascular Aging Program, UAMS
Jeanne Y. Wei, M.D., Ph.D., the Jackson T. Stephens Professor of Geriatrics; chair, Reynolds Department of Geriatrics, College of Medicine; executive director, Reynolds Institute on Aging, UAMS, and
Summary: The Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults (PREVENTABLE) trial is a multi-center study that will follow adults ages 75 and above without cardiovascular disease for five years as they receive either atorvastatin 40 mg or a placebo.
Significance: This large study aims to demonstrate the benefit of statins for reducing the primary composite of death, dementia and persistent disability and secondary composites including mild cognitive impairment and cardiovascular events.
TRI Services: Medicare coverage analysis, study budget development, regulatory management, biomedical informatics/clinical data extracts through the TRI-supported UAMS/Arkansas Clinical Data Repository (AR-CDR) and Epic support.
Sponsor/Clinical Coordinating Center: Duke University
Funding Agency: National Institute on Aging