In this month’s TRIbune newsletter, we highlight the productive collaboration of two KL2 Program Scholars, Maryam Garza, Ph.D., and Tremaine Williams, Ed.D. Since establishing their collaboration last year, Garza and Williams have generated three publications and an R01 application. We also note an important KL2 Information Session for prospective applicants on Oct. 6, as well as a Path 2 K Grant Writing Program led by Mario Schootman, Ph.D.

This issue also reports the outcome of TRI’s Summer Writing Challenge 2022, and Our Study of the Month features Sukanthi Kovvuru, M.D., in the Department of Neurology.

Read The TRIbune.

Jennifer L. Vincenzo, Ph.D., MPH, PT, recently became the first UAMS researcher to receive the national Paul B. Beeson Emerging Leaders Career Development Award in Aging, which comes with $1 million over five years.

The award will support Vincenzo’s work implementing a falls prevention strategy as a standard of care for all older adults attending outpatient physical therapy clinics. Her work has been supported by a TRI KL2 Mentored Research Career Development Award. 

The Beeson award stems from an initiative by the National Institute on Aging (NIA) at the National Institutes of Health (NIH), the American Federation for Aging Research, and the John A. Hartford Foundation. Their aim is “to develop a cadre of talented scientists prepared and willing to take an active leadership role in transformative change that will lead to improved health care outcomes,” according to the American Federation for Aging Research website.

Vincenzo is only the third physical therapist to receive the award, which typically goes to medical doctors.

“I am honored to be a Beeson Scholar and represent UAMS,” said Vincenzo, an associate professor in the College of Health Professions Department of Physical Therapy. “This award will allow me to address the public health issues of falls among older adults, which are a leading cause of morbidity, mortality and decreased quality of life.”

The Beeson award will help her integrate her falls prevention self-management plan that she developed in the last three years with the STEADI (Stopping Elderly Accidents, Deaths & Injuries) toolkit developed by the Centers for Disease Control and Prevention (CDC). The STEADI toolkit, established in 2012 for physicians to integrate falls prevention into daily practice, has not been widely adopted, but Vincenzo wants to change that. Her goal is to work with stakeholders to implement the integrated program as a standard of care in outpatient physical therapy clinics, starting at UAMS.

Vincenzo established her fall prevention self-management plan through work supported by a UAMS Translational Research Institute KL2 Mentored Research Career Development Award. She credits the KL2 support that began in 2019 as a key to her success. She received two years (plus a one-year extension) of salary support, research funding, and translational research training, including training in implementation science.

“I would not be where I am without the support of UAMS, the Translational Research Institute, and especially my colleagues in the Department of Physical Therapy,” she said. “The Beeson award will allow me to advance my knowledge and skills as an implementation scientist in aging under the mentorship of Geoffrey Curran, Ph.D., and Jeanne Wei, M.D., Ph.D., who also served as mentors on my KL2.”

Curran is director of the UAMS Center for Implementation Research and professor of pharmacy practice in the College of Pharmacy. Wei is executive director of the UAMS Donald W. Reynolds Institute on Aging and chair of the Donald W. Reynolds Department of Geriatrics in the College of Medicine.

Translational Research Institute Director Laura James, M.D., said Vincenzo’s success is a great example of how the KL2 program can prepare talented early-career researchers and help them fast track their research programs.

“Dr. Vincenzo has seized on the opportunities provided by the KL2 program, developing and advancing a plan with significant promise for reducing falls among older adults,” said James, UAMS associate vice chancellor of Clinical and Translational Research. “She has also positioned herself for even greater success as a leader in her field.”

Vincenzo’s KL2 work led to state and national leadership appointments, including chair of the Balance and Falls Special Interest Group – American Physical Therapy Association-Geriatrics (APTA-G); and a member of the APTA-G Board.  She is also chair of the Governor’s Advisory Council on Aging in Arkansas.

The KL2 program at the Translational Research Institute is supported by the National Center for Advancing Translational Sciences at the National Institutes of Health, Clinical and Translational Science Award KL2 TR003108.

The UAMS Translational Research Institute (TRI) and UAMS Center for Implementation Research (CIR) have selected five clinical faculty as 2023 Implementation Science Scholars. Using the principles of implementation science, CIR faculty will guide the scholars through 10 didactic sessions per year and provide oversight and mentoring for their experiential implementation science projects. The two-year program will provide 20% salary support (up to salary cap).

The scholars and their project titles are:

Stephen Foster, M.D., assistant professor, College of Medicine Department of Family and Preventive Medicine, UAMS Northeast Regional Campus

Project: Improving Outcomes for Patients with Chronic Obstructive Pulmonary Disease in the Primary Care Setting through Electronic Health Record Optimization

Chelsea Mathews, M.D., assistant professor, College of Medicine Department of Orthopaedic Surgery, UAMS and Arkansas Children’s Hospital

Project: Improving the Patient Experience through Journey Mapping at the Orthopaedic and Spine Hospital (under construction at UAMS)

Veronica M. Raney, M.D., assistant professor, College of Medicine Department of Psychiatry; interim director, Division of Child and Adolescent Psychiatry; medical director, Child Study Center, UAMS 

Project: Implementation of Specialized Mental Health Services to Address Gaps in Care for Transitional Age Youth (TAY)

Jarna Shah, M.D., assistant professor, College of Medicine Department of Anesthesia, Chronic Pain Division, UAMS

Project: Implementation of Nutrition Screening in Patients Undergoing Elective Joint Replacement Surgery

Shruti Tewar, MBBS, MPH, associate professor, College of Medicine Department of Pediatrics, Division of Developmental and Rehabilitative Medicine, UAMS

Project: Implementation of Guidelines for Medication Management of Complex ADHD in Children

UAMS-affiliated researchers who have received Translational Research Institute (TRI) support submitted 77 research manuscripts as part of the Summer 2022 Writing Challenge, TRI Director Laura James, M.D., announced at an Ice Cream Social celebration to recognize the contributing researchers.

Held jointly at UAMS campuses in Little Rock and Northwest Arkansas, the Thursday, Sept. 8 event featuring Loblolly Creamery ice cream included prizes in six categories and numerous door prizes.

“We are thrilled to have received so many manuscript submissions and nearly match our total of 85 a year ago,” James said. “This is a huge accomplishment, reflecting the dedication of our faculty to complete an important part of research, which is the dissemination of research findings. In particular, the enthusiasm of our junior faculty is noteworthy and reflects the energy and vibrancy of our early-stage researcher community.”

Below are the winners announced at Thursday’s event:

Jennifer Andersen, Ph.D.
Astounding Apprentice Award: Most Submitted Manuscripts (seven) for the Rank of Assistant Professor/Instructor
Prize: TRI will pay for a manuscript submission fee

Chenghui Li, Ph.D.
Wise Wordsmith Award: Most Submitted Manuscripts (four) for the Rank of Associate Professor
Prize: Free statistical consultation

David Ussery, Ph.D.
Sage Scribe Award: Most Submitted Manuscripts (four) for the Rank of Professor
Prize: TRI will submit a manuscript

Zulema Udaondo, Ph.D.
Best Representation of Informatics Supported Research
Prize: Wooden pen set

Melissa Zielinski, Ph.D.
Best Representation of Implementation Science
Prize: UAMS tumbler

Jennifer Andersen, Ph.D.
Most Reflective of Community Engagement and Partnerships
Prize: UAMS travel blanket

Umesh Wankhade, Ph.D., won a special door prize added this year, “A Delightful Dinner with the Director (James).”  

The 77 total submissions included:

• 14 submissions from Professors
• 16 submissions from Associate Professors
• 37 submissions from Assistant Professors
• 10 submissions from staff/others.

UAMS Investigators: Gohar Azhar, M.D., professor, Department of Geriatrics; director of Clinical Research, director of the Pat Walker Memory Clinic and Research Center, and co-director of the Cardiovascular Aging Program, UAMS

Jeanne Y. Wei, M.D., Ph.D., the Jackson T. Stephens Professor of Geriatrics; chair, Reynolds Department of Geriatrics, College of Medicine; executive director, Reynolds Institute on Aging, UAMS, and

Summary: The Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults (PREVENTABLE) trial is a multi-center study that will follow adults ages 75 and above without cardiovascular disease for five years as they receive either atorvastatin 40 mg or a placebo.

Significance: This large study aims to demonstrate the benefit of statins for reducing the primary composite of death, dementia and persistent disability and secondary composites including mild cognitive impairment and cardiovascular events.

TRI Services: Medicare coverage analysis, study budget development, regulatory management, biomedical informatics/clinical data extracts through the TRI-supported UAMS/Arkansas Clinical Data Repository (AR-CDR) and Epic support.

Sponsor/Clinical Coordinating Center: Duke University

Funding Agency: National Institute on Aging

Patients previously hospitalized with COVID-19 had a 45% higher risk of heart failure than other hospitalized patients, according to the first national study of its kind, which was co-authored by a University of Arkansas for Medical Sciences (UAMS) researcher.

Lead author Husam M. Salah, M.D., at UAMS said the findings reported in Nature Communications also revealed an even higher risk of heart failure for younger, white patients previously hospitalized with COVID-19, surprising the research team.

“We were seeing this increased trend in heart failure among patients previously hospitalized for COVID-19, but until our study, we did not have evidence to confirm the relationship to COVID-19,” said Salah, chief medical resident in the College of Medicine Department of Medicine. “Inflammation of the heart muscle and the coronary arteries as well as formation of small clots in the coronary arteries caused by COVID-19 may be major players in the association between COVID-19 and heart failure.”

Previously hospitalized COVID-19 patients under age 65 were at 53% greater risk of heart failure compared to a 38% increased risk in those 65 and older. Patients who were white (all ages) saw a 49% increased risk compared to a 36% risk in nonwhite or Hispanic patients.

“This really surprised us,” Salah said. “We don’t have an explanation. It might be that these patients had a more severe cardiac inflammatory response.”

The study analyzed de-identified data of 587,330 patients in the National COVID Cohort Collaborative (N3C) database, created by the National Institutes of Health (NIH) and its National Center for Advancing Translational Sciences, which also funds the UAMS Translational Research Institute.

The study of the heart failure association with previously hospitalized COVID-19 patients was the first using such a large-scale nationally representative population, according to the article.

“The N3C was one of the very few databases that had nationally representative de-identified COVID-19 related data,” Salah said.

The findings will be of value to doctors who treat previously hospitalized COVID-19 patients, he said.

“As a physician, it’s important to know the complications of COVID-19,” he said. “Knowing the association with heart failure will help guide the care for previously hospitalized COVID-19 patients.”

UAMS is among the early contributors of de-identified patient data to the N3C. It continues to aid the national effort with expertise and leadership by Fred Prior, Ph.D., chair and distinguished professor in the College of Medicine Department of Biomedical Informatics, and Ahmad Baghal, M.D., Ph.D., who directs the Arkansas Clinical Data Repository, a UAMS database of historical patient data.

Their efforts have been supported by the UAMS Translational Research Institute, led by Laura James, M.D., who co-chairs the National Center for Advancing Translational Sciences Clinical and Translational Science Awards Program Steering Committee.

“The Nature Communications article is a great example of the translational research that is possible with the N3C,” said James, also UAMS associate vice chancellor for Clinical and Translational Research. “It is especially gratifying to see the N3C database contributing to such important work with a UAMS researcher as part of the team.”

Other study co-authors are from Duke University, University of Colorado Anschutz, Johns Hopkins University, University of North Carolina, North Carolina State University and Palantir Technologies.

In this month’s TRIbune newsletter, we’re highlighting the success of three TRI entrepreneurship trainees: Samir Jenkins, Ph.D., Amanda Stolarz, Ph.D., and Aaron Storey, Ph.D. Stolarz participated in a 2016 TRI-supported training, and Jenkins and Storey were part of the 2019 inaugural class of TRI Health Science Innovation and Entrepreneurship (HSIE) Program. All are advancing translational research using their TRI supported training and NIH small business funding. 

Our TRI Study of the Month features UAMS’ Gohar Azhar, M.D., and Jeanne Y. Wei, M.D., Ph.D., and their work on a multi-center study of lipid lowering in older adults.

We also highlight the six UAMS researchers who are part of two research projects that received TRI Team Science Voucher Awards.

Read The TRIbune.

UAMS’ Erhan Ararat, M.D., and Laura Gressler, Ph.D., have been named TRI Data Scholars for 2022.

Ararat is an assistant professor in the College of Medicine Department of Pediatrics.

Project title: “Evaluation of Metformin for the Symptoms and treatment of Asthma on a Pediatric Population.”

Gressler is an assistant professor in the College of Pharmacy Division of Pharmaceutical Evaluation and Policy.

Project title: “Leveraging Natural Language Processing Methodologies for the Refinement of Signal Detection Algorithms in Electronic Health Records.”

As part of the one-year program, data scholars receive close mentoring from UAMS faculty in conducting a data-oriented research project. They also receive 20% salary support and reimbursement for tuition and fees up to $5,000 to support coursework in data science or data analytics.