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  1. University of Arkansas for Medical Sciences
  2. Translational Research Institute
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  4. Page 2

News

TRI, 5 Rural CTSAs Seek Multi-institutional Pilot Applications for Translational Science Projects 

Image of logos of Consortium of Rural States (CORES) institutions with deadlines for submissions, which are repeated in the story.

The Consortium of Rural States (CORES) Multi-institutional Pilot Program will fund translational science projects aiming to identify and overcome barriers to the performance of translational research.

Awards of up to $25,000 per institution will go to the collaborators for projects involving two or more of the six CORES institutions.

View a recording of the CORES Information Session.

The CORES pilot opportunity includes four emphasis areas: 

  • Climate Change and Environmental Health
  • Health Equity for Underrepresented Populations
  • Rural Health 
  • Maternal Health

All UAMS-affiliated faculty are invited to apply.

Letters of Intent are due Jan. 18, 2023.

Invited full applications are due March 8, 2023. 

In addition to UAMS, the collaborative includes the University of New Mexico Health Sciences Center, University of Kansas Medical Center, University of Kentucky, University of Iowa and University of Utah Health.

If you have questions about this pilot project award, please contact TRI’s Crystal Sparks, csparks@uams.edu.

Read the Request for Applications.

Filed Under: Front, News, Newsroom

TRI Study of the Month

Kyle Kalkwarf, M.D., is assisted on the trial by TRI’s Shellah Rogers, B.S.N., RN, CMSRN, the study’s lead clinical research coordinator.
Kyle Kalkwarf, M.D., is assisted on the trial by TRI’s Shellah Rogers, B.S.N., RN, CMSRN, the study’s lead clinical research coordinator.  

UAMS Principal Investigator: Kyle Kalkwarf, M.D., assistant professor, College of Medicine Department of Surgery, Division of Trauma and Acute Care Surgery

Summary: This multi-site clinical trial involving hospitalized traumatic brain injury patients will test the effectiveness of a non-invasive device (Infrascanner) for detecting the growth of intracranial hematomas.

Significance: The study of this FDA-approved device, which uses near-infrared light to detect bleeding, may lead to earlier diagnosis and improved treatments for traumatic brain injury patients, especially in areas with limited resources, such as rural America or on military deployments

TRI Services: Medicare coverage analysis, study budget development, regulatory and nurse/clinical coordinator support, administration of Clinical Trial Management System, and post-award financial management

Sponsor: University of Alabama at Birmingham

Funding: U.S. Department of Defense

Filed Under: Front, News, Newsroom, Uncategorized

The TRIbune Is Here

STARs participant Bolni “Marius” Nagalo, Ph.D., here in his lab at the UAMS Winthrop P. Rockefeller Cancer Institute, said the grant-writing program was a “fantastic” experience. Photo by Evan Lewis
STARs participant Bolni “Marius” Nagalo, Ph.D., here in his lab at the UAMS Winthrop P. Rockefeller Cancer Institute, said the grant-writing program was a “fantastic” experience. Photo by Evan Lewis

In this issue of The TRIbune, we feature the achievements of researchers who participated in our Strategies for Training and Advancing underrepresented Researchers (STARs) program in fall 2021. Participants described the program as “invaluable” and “fantastic” and have since secured career development awards, supplemental grants and internal funding. In addition:

We highlight Britni Ayers, Ph.D., a former TRI KL2 scholar, who received a $420,750 NIH grant for her research involving pregnant Marshallese women.

We introduce the four community groups selected to TRI’s Community Partners Educated as Arkansas Research Leaders (CPEARL) Program.

And our TRI Study of the Month features Kyle Kalkwarf, M.D., a TRI Implementation Science Scholars Program awardee, for his leadership on a clinical trial involving traumatic brain injury patients.

Read The TRIbune.

Filed Under: Front, News, Newsroom

TRI’s Tracy Thurman Named Clinical Billing Compliance Champion for 2022

TRI's Tracy Thurman (right) received the UAMS Compliance Champion Award from Amy Jones, senior director of UAMS Clinical Billing Compliance.
TRI’s Tracy Thurman (right) received the UAMS Compliance Champion Award from Amy Jones, senior director of UAMS Clinical Billing Compliance.

The UAMS Office of Institutional Compliance recognizes Corporate Compliance and Ethics Week each year during the first week of November. 

This year, Tracy Thurman, B.S., CCRP, clinical research finance manager for the UAMS Translational Research Institute (TRI), is UAMS’ Clinical Billing Compliance Champion. She was selected for going above and beyond in her adherence to compliance and maintaining positive, supportive relationships with compliance office employees and other members of Team UAMS.

Below is the narrative submitted with her nomination:

“Tracy Thurman is the Clinical Research Finance Manager in TRI. Tracy and the TRI team provide vital services for clinical research areas, such as Medicare Coverage Analysis, building budgets, negotiating budgets with sponsors, and reviewing billing charges for clinical research studies out of TRI.

Tracy has an invaluable depth of knowledge in her field and always strives to help ensure that billing for clinical research studies is set up to ensure compliance. Tracy and her fellow team members work with many areas on campus such as the UAMS Billing Offices, the Value Analysis Office and the UAMS Compliance Office.

Tracy is well respected by her peers. She is always kind, professional and respectful. She is one of the many employees in TRI who help to foster compliance in clinical research that allows UAMS to continue to offer ground-breaking clinical research opportunities for our community. UAMS is very fortunate to have Tracy on TEAM UAMS!”

As part of this awareness, recognition, and reinforcement campaign, each division within Compliance selected Team UAMS members who demonstrate outstanding support to UAMS compliance programs.

Read more here about other 2022 Compliance Champions.

Filed Under: Front, News, Newsroom

Former KL2 Scholar Using NIH Grant to Address Urgent Health Needs of Pregnant Marshallese Women

Britni Ayers, Ph.D., a former TRI KL2 scholar, is leading the study involving small groups of pregnant Marshallese women and health care navigators to improve health outcomes. 

A University of Arkansas for Medical Sciences (UAMS) research team in Northwest Arkansas will study a potential way to improve health outcomes of pregnant Marshallese women using group-based care and health care navigators.

Led by former UAMS Translational Research Institute KL2 Scholar Britni Ayers, Ph.D., the study of maternal health care involving small groups of women, known as CenteringPregnancy, is funded by a two-year, $420,750 grant from the National Institute of Nursing Research at the National Institutes of Health (NIH).

Pacific Islanders/Marshallese living in the United States have almost twice the infant mortality rate as non-Hispanic whites. Arkansas is home to the country’s largest population of Marshallese, about 14,000 residents.

Ayers’ preliminary research has found that 15% of Marshallese women in Arkansas received no prenatal care (compared to 1.6% women nationally); more than 50% do not attend the recommended number of prenatal care visits; 19% of Marshallese infants were born preterm (compared to 9.6% nationally); and 15% of Marshallese infants were low birthweight (compared to 8.3% nationally).

Marshallese women face a number of barriers to medical care, including language, transportation and lack of information to help navigate the medical system and access resources.

“They are fearful of the medical system,” said Ayers, an assistant professor at UAMS Office of Community Health & Research in Springdale. “It’s ubiquitious — Marshellese women have expressed fear of the prenatal care process in all of our focus group interviews.”

Ayers hopes her CenteringPregnancy research will show that it is effective and can be used on a larger scale.

“Pregnant Marshallese women in Arkansas are experiencing urgent health needs, and we have the potential to move the needle tremendously with this type of concept,” she said.

CenteringPregnancy programs have proved effective in other areas of the United States, but it has not been tried with Pacific Islanders/Marshallese women. It should be a good fit for the population, Ayers said.

“The Marshallese culture is collectivist. They value the group more than the individual, so I think any sort of group health care will be a better way to reach this population,” she said.

Ayers will recruit 40 Marshallese women to take part in 90-minute small-group sessions. The sessions will include a bilingual CenteringPregnancy-trained Marshallese registered nurse and other prenatal health professionals providing brief one-on-one examinations and leading discussion of pregnancy topics at each of the 10 prenatal sessions. Additionally, all participants will be provided a bilingual Marshallese care navigator to aid in assessment and enrollment in social support services.

Over the last two years, Ayers used research pilot funding and training from a UAMS Translational Research Institute KL2 Mentored Research Career Development Award to help secure the NIH grant.

The Translational Research Institute is supported by a Clinical and Translational Science Award from the NIH National Center for Advancing Translational Sciences, grant UL1 TR003107.

Filed Under: Front, News, Newsroom

The October TRIbune Is Here!

In this issue of The TRIbune, we feature an exciting new software program that will simplify TRI grant application processes for researchers, reviewers and our staff. The Apply software program will be available in spring 2023 for six TRI funding opportunities. The program will provide a tool that not only streamlines processes but also ensures that TRI’s funding programs are equitable, fair and transparent.

TRI’s Paul Duguid, MPH, and Carolyn Greene, Ph.D., are leading TRI’s acquisition of the Apply software.
TRI’s Paul Duguid, MPH, and Carolyn Greene, Ph.D., are leading TRI’s acquisition of the Apply software.

We also highlight our latest cohort of Strategies for Training and Advancing underrepresented Researchers (STARs) program recipients and the recent national award for Jennifer Vincenzo, Ph.D., which stems from her work as a KL2 Mentored Research Career Development Program scholar.  

Our Study of the Month features Erika Petersen, M.D., a professor of neurosurgery, and her collaborations with Ranu Jung, Ph.D., at the University of Arkansas, Fayetteville Institute for Integrative & Innovative Research (I3R), and UAMS orthopaedic surgeons John Bracey Jr., M.D., and Mark Tait, M.D.

Read The TRIbune.

Filed Under: Front, News, Newsroom

Five UAMS Researchers Receive TRI Pilot Awards

New TRI pilot awardees, clockwise from top left: Stanley Ellis, Ed.D., Susan Emmett, M.D., Megan Smith, Pharm.D., Lindsey Wolf, M.D., and Michael Thomsen, Ph.D.
New TRI pilot awardees, clockwise from top left: Stanley Ellis, Ed.D., Susan Emmett, M.D., Megan Smith, Pharm.D., Lindsey Wolf, M.D., and Michael Thomsen, Ph.D.

The UAMS Translational Research Institute has named five UAMS researchers who will receive pilot grants of up to $50,000 each for studies that impact rural health.

The one-year awards went to projects led by researchers in the College of Medicine, College of Pharmacy and Fay W. Boozman College of Public Health. They are: 

Stanley K. Ellis, Ed.D., M.S., associate professor, College of Medicine Department of Obstetrics and Gynecology; director of Education, Institute for Digital Health & Innovation.

Project: School-Based Tele-counseling Feasibility Pilot

Susan Emmett, M.D., MPH, associate professor, College of Medicine Department of Otolaryngology-Head and Neck Surgery, and director of the Center for Hearing Health Equity

Project: Achieving Hearing Health Equity for Rural Children: Optimization of a Novel Mobile Health Tympanometer for Community-Based Hearing Screening

Megan Smith, Pharm.D., BCACP, assistant professor, College of Pharmacy Department of Pharmacy Practice
Project: Evaluation of the Integration of Community Health Workers (CHW) into Rural Community Pharmacies

Michael Thomsen, Ph.D., professor, Governor Sidney S. McMath Chair in Obesity Prevention, director of the Center for the Study of Obesity, Fay W. Boozman College of Public Health

Project: Understanding Rural Disparities in Severe Obesity through the Arkansas Childhood Body Mass Index Panel

Lindsey Wolf, M.D., assistant professor, College of Medicine Department of Surgery, Division of Pediatric Surgery

Project: A Pilot Program to Evaluate the Feasibility of Telemedicine Pediatric Surgical Consultations in Referring Emergency Departments

Filed Under: Front, News, Newsroom

TRI Study of the Month

Sukanthi Kovvuru, M.D., consults with TRI’s Simone Walls, MBA, MPH, CHES, CRS, regulatory specialist for the HEALY ALS Platform Trial.
Sukanthi Kovvuru, M.D., consults with TRI’s Simone Walls, MBA, MPH, CHES, CRS, regulatory specialist for the HEALY ALS Platform Trial.

UAMS Principal Investigator: Sukanthi Kovvuru, M.D., assistant professor, College of Medicine Department of Neurology

Summary: The HEALY ALS Platform Trial is a multi-center, multi-regimen clinical trial evaluating the safety and efficacy of multiple investigational products for the treatment of Amyotrophic Lateral Sclerosis (ALS). UAMS will begin with Regimen E – SLS-005 Trehalose and a matching placebo.

Significance: Researchers hope that the trial can identify a safe drug that will slow ALS’ rate of progression and/or improve ALS symptoms.

TRI Services: Medicare coverage analysis, study budget development, regulatory management, clinical/nurse coordinator and finance support.

Sponsor/Clinical Coordinating Center: Merit Cudkowicz, M.D., Director, Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital

Filed Under: News, Newsroom

TRI Employees Raise Funds, Serve Meals at Our House

Residents of Our House recently enjoyed a lunch and dinner courtesy of employees at the UAMS Translational Research Institute (TRI).

TRI volunteers at lunch were: (left side, front to back) Ladiedra Donahue, Ty Stacey (lead), Lasha Fite, Paul Duguid (lead); (right, front to back) Vallon Williams, Simone Walls, David Avery and Chaz England.

With staff donations totaling almost $900, the TRI Employee Council was able to prepare homemade meals for 30 residents at lunch and 75 residents at dinner. Lunch included oven-baked barbecue chicken sandwiches, baked beans, coleslaw and Rice Krispie treats. The dinner menu was lasagna, fresh salad, garlic bread and homemade fresh baked cookies.

TRI’s Crystal Walter (front), Crystal Sparks and Paul Duguid prepare trays for the evening meal.

Our House’s mission is to empower homeless or near-homeless families and individuals to succeed in the workforce, school, and life through hard work, wise decision-making and active participation in the community.

TRI volunteers provided about 30 meals to Our House residents at lunch and about 75 were served at dinner.
TRI volunteers provided about 30 meals to Our House residents at lunch, and about 75 were served at dinner.

“We are super thankful for organizations like the UAMS Translational Research Institute who come out and help their community in such a big way by serving meals for the residents at Our House,” said Caroline Robbins, Our House development director. “Preparing meals and gathering around a meal table include a lot of components of what building a community around yourself looks like, and we value partners who are willing to take the time to do that with our clients every single month.”

Paul Duguid, MPH, leads the TRI Employee Council, which organized the community service project.

“I’m happy to work where the staff are committed to teamwork and service to our community,” said Duguid, assistant director of Funding Programs. “My TRI colleagues consistently rally around events to give back to those in the community, both on and off campus, and I’m incredibly proud of working shoulder to shoulder to prepare and serve meals at Our House with them.”

TRI volunteers were: Paul Duguid (lead), Ty Stacey (lead), David Avery, Lasha Fite, Chaz England, LaDiedra Donahue, Laura James, M.D., Robin Liston, Crystal Sparks, Simone Walls, Crystal Walter, and Vallon Williams.

Filed Under: Employee Spotlight, News, Newsroom

KL2 Meeting Sparks Junior Investigators’ Collaboration, Three Publications

Maryam Garza, Ph.D., and Tremaine Williams, Ed.D., share a laugh during a recent meeting.
Maryam Garza, Ph.D., and Tremaine Williams, Ed.D., share a laugh during a recent meeting.

A routine monthly meeting, a comment and a question were the genesis for three publications this year by two TRI KL2 Mentored Research Career Development Program scholars.

Maryam Garza, Ph.D., MPH, MMCi, and Tremaine Williams, Ed.D., who became KL2 scholars in 2021, are co-authors on papers in BMC Medical Research Methodology; Journal of Multimorbidity and Comorbidity; and Journal of the American Medical Informatics Association.

For Garza and Williams, assistant professors in the College of Medicine Department of Biomedical Informatics, their early success speaks to the testimonies they have heard about the power of collaboration and team science.

“As early career investigators and KL2 scholars, we’re trying to carry out our research, write papers and grants, and it’s a lot to get done by yourself,” Garza said. “So collaboration is really helpful to get you out of any holes and elevate the quality of the work. It is also much more enjoyable to not be alone in this work.”

Williams agreed. “When I’ve taken a project as far as I can, I know I can go to Maryam and she will have some questions, suggestions or substantial contributions to guide the direction of the work.”

The two realized the opportunity for collaboration during a regular monthly meeting of the KL2 scholars as Williams gave his status report. He heard Garza say, “Ooh, I didn’t realize how much our worlds intersect.”

Her comment prompted him to ask the group if anyone was interested in collaborating. “Maryam was the first person to say, ‘Yes, I would love to collaborate,’ so it went from there,” he said.

Both are working in the area of data quality, and their worlds intersect at how to streamline processes of getting that data from point A to point B.

Garza’s work is focused on overcoming data-related barriers that slow the search for cures and vaccines.

“Informatics has a critical role to play improving the data pipeline, which will translate to more efficient bench-to-bedside processes,” Garza said. “No one can run clinical trials and leverage the electronic health record if the data doesn’t exist.”

John Arthur, M.D., Ph.D.
John Arthur, M.D., Ph.D.

Williams’ work has focused on expanding the informatics capacity of the electronic health record to support patients with two or more chronic conditions, referred to as multimorbidity patients.

“These multimorbidity patients are behind the curve because medical care has been traditionally siloed into addressing single chronic diseases, and the data we have is a byproduct of those treatments,” he said. “The informatics infrastructure is lagging. We don’t have, for example, clinical data repositories or places that could support very robust, global clinical and translational research for multimorbidity patients.”

He noted that Garza is working on an emerging data standard called HL7® FHIR® (Fast Healthcare Interoperability Resources 1 ), which defines how health care information can be transferred between information systems regardless of how those systems store it.

Elisabet Borsheim, Ph.D.
Elisabet Borsheim, Ph.D.

“Maryam is going to change the world with the work that she’s doing to enable the use of real world data in real time,” Williams said. “But we can’t apply much of Maryam’s work on the FHIR standards with multimorbidity patients because most health care systems don’t currently have the data infrastructure needed for the management and longitudinal tracking of the compounding of chronic diseases.”

TRI Associate Director John Arthur, M.D., Ph.D., co-director of the KL2 Program, praised Garza and Williams for their enthusiastic collaboration.

“They are setting a great example for their colleagues in the KL2 Program as well as our entire research community,” said Arthur, also chief of the Division of Nephrology in the Department of Internal Medicine. “I am excited by the strength of their work and happy that the KL2 Program became a conduit for their collaboration.”

Williams said the collaboration was enabled in large part because of the tone set by the KL2 Program leaders, Arthur, Elisabet Borsheim, Ph.D., and Carolyn Greene, Ph.D.

Carolyn Greene, Ph.D.
Carolyn Greene, Ph.D.

“The environment in the monthly KL2 meetings is very warm, very supportive,” Williams said.

Hoping to capitalize on their efforts, Garza and Williams recently submitted an R01 grant application to the National Institutes of Health. And beyond that, they are dreaming big.

“We are going to grow old together as collaborators,” Garza said, “and who knows, maybe we’ll win the Nobel Prize.” 

Filed Under: News, Newsroom

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