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Visiting Latino Leader, Scholar to Give Three Lectures March 16, 17

UCLA Distinguished Professor of Medicine David E. Hayes-Bautista, Ph.D., who has spent decades studying and writing about the links between culture, behavior and health, will give three presentations in Little Rock on March 16 and 17.

The UAMS Translational Research Institute is sponsoring a reception following his March 16 presentation, “Latino Leadership and the Cinco de Mayo in the American West,” from 6-7 p.m., at the Clinton School of Public Service, Sturgis Hall, 1200 President Clinton Ave. 

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Hayes-Bautista is director of the Center for the Study of Latino Health and Culture at the UCLA David Geffen School of Medicine. For the past five years, he has been chosen one of the 101 Top Leaders of the Latino Community in the U.S. by Latino Leaders Magazine. In 2012, he received the Association of American Medical Colleges (AAMC) Herbert W. Nickens Award for his lifelong concerns about the educational, societal, and health care needs of underrepresented groups.

For more than three decades he has studied the “Latino Epidemiological Paradox,” the tendency of Latino Americans to have health outcomes comparable to or better than their non-Hispanic white counterparts in the U.S., and the implications of this paradox for populations, chronic diseases and communicable diseases. 

To join the March 16 lecture at ACH via live streaming on your PC, MAC, iPad or iPhone:

  1. Visit www.archildrens.org/video
  2. Click on the Peds PLACE icon
  3. Click on the topic and date listed above (or search)
  4. If watching LIVE, remember that you can send in questions for the speaker

April 12 Webinar: Learn How to Conduct Multisite Clinical Trials with a Single IRB

The first SMART IRB webinar on April 12, 3:30 – 4:30 p.m., will provide an overview of the SMART IRB Online Reliance System, which will be available to researchers later this spring. UAMS is among the Clinical and Translational Science Award (CTSA) Consortium SMART IRB participating institutions.

The Online Reliance System is a unique tool that helps institutions establish and document single IRB review arrangements. By using this system:

  • Investigators can create and submit requests to use a single IRB for their studies.
  • Collaborating institutions can work together to identify a Reviewing IRB and track and document reliance arrangements on a study-by-study basis.
  • Users have a clear understanding of next steps and are notified when action is required.

The webinar will be led by Nichelle Cobb, Ph.D., chief regulatory operations officer for Implementation for SMART IRB, and director of the Health Sciences IRBs Office at the University of Wisconsin-Madison.

Register for Webinar

 

TRI Changes Process for Study Budget Development & Negotiations

The Translational Research Institute (TRI) Clinical Trials Innovation Unit (CTIU) recently revised the process for investigators submitting studies that require a Medicare coverage analysis and budget in CLARA.  

In addition to conducting full Medicare Coverage Analysis, CTIU’s Research Finance Team (RFT) offers full budget development and/or negotiation services for all non-cancer-related protocols requiring a budget. To access all services, the investigator or designee submits a request through the TRI services portal. RFT members will work with investigators and their team to complete the budget, coverage and legal process in an efficient manner.

To increase efficiency and provide feasibility data to investigators, the RFT has altered the order of its coverage and budget activities, performing the Medicare Coverage Analysis prior to budget development and review. If investigators and their team wish to develop and/or negotiate the budget themselves, the RFT highly encourages them to submit the required study documents to the RFT prior to starting budget development. The RFT will provide a Medicare Coverage Analysis Report (MCAR) that is sent to the investigator for approval and can be used as a guide for budget development. 

It is not mandatory to obtain a MCAR prior to budget development. However, if the budget is developed prior to the MCAR it will likely delay the budget approval process for the study. If investigators or study teams have questions about this process, contact Jonathan Young, JAYoung@uams.edu, 526-7984.

UAB Entrepreneur to Speak at HSE Seminar, March 1

The next Health Sciences Entrepreneurship Seminar will feature Erik Schwiebert, Ph.D., from the University of Alabama, Birmingham (UAB), speaking March 1, from 5 – 6 p.m. at the Reynolds Institute on Aging, Jo Ellen Ford Auditorium. 

Schwiebert will present “New Paradigms for Scientist to CEO Transition and New Biotechnology Startup Creation.”

DiscoveryBioMed, Inc. is a Birmingham-based life sciences and biotechnology company, with the goal of integrating human cell physiology with the drug discovery critical path. Schwiebert, a physiologist, launched the company in October 2007. Since then DiscoveryBioMed has continued to grow and gain recognition both locally and nationally.

The UAMS Seminar Series is being offered in collaboration with UAB, University of Kansas Medical Center and the University of Utah – all Clinical and Translational Science Award (CTSA) institutions. The series is sponsored by the NIGMS Systems Pharmacology and Toxicology T32 Training Program, UAMS Translational Research Institute (TRI) and UAMS BioVentures.

If you missed last month’s seminar featuring UAMS’ Amy Hester, Ph.D., watch it here

Researchers Urged to Complete GCP Training

The NIH Policy on Good Clinical Practice (GCP) Training became effective January 1, 2017. This policy applies to NIH-funded investigators and site staff who are responsible for the conduct, management and oversight of NIH-funded clinical trials. An NIH Clinical Trial is defined as Research studies in which one or more human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes.  An intervention is defined as a manipulation of the subject or subject’s environment for the purpose of modifying one or more health-related biomedical or behavioral processes and/or endpoints.

If you are conducting an NIH-funded clinical trial, you will need to complete your training as soon as possible. There are several ways to do this: 

  1. Complete GCP training using the CITI program at https://www.citiprogram.org/. Log in using the user ID and password that you used for your human subjects protection training, scroll down past the list of courses you have completed and select Add a Course. Select Good Clinical Practice (GCP) Basic Course.
  2. Complete NIH-developed GCP training. Send completion certificate to Catrice Banks-Johnson in the Office of Research Compliance (CRBanksjohnson@uams.edu). 
  3. For social and behavioral researchers, you can log onto Blackboard and complete the NCATS-developed GCP training.  View documents for the GoSignMeUp registration process and basic navigation functions for the Blackboard Course. A Certification of Completion will be generated upon the conclusion of the final module.  Send completion certificate to Catrice Banks-Johnson in the Office of Research Compliance (CRBanksjohnson@uams.edu).
  4. Send record/certificate of current GCP training (i.e., from industry-sponsored trial participation, from ACRP or SoCRA certification, or from completion of UAMS Graduate School courses PHSC6043 or PGSP6101) to Catrice Banks-Johnson (CRBanksjohnson@uams.edu). 

For options 2-4 above, Catrice will record this training in Training Tracker for you upon receipt of your completion certificate.  

NOTE: GCP training expires after three years.

If you have ambitions of conducting an NIH-funded clinical trial, you are highly encouraged to complete the training now!  

Even if you have determined this does not apply to you, you are highly encouraged to complete the training now!  GCP training is likely to be mandated within the next 6-12 months, as many institutions, journals, and other funding sources are trending toward this requirement.

The UAMS Office of Research Compliance will conduct random audits to ensure compliance with this policy.

If you have any questions, please contact one of the following institutional offices:

Amy Jo Jenkins
TRI
686-5939
ajjenkins@uams.edu

Jennifer Holland
IRB
526-7559
jrholland@uams.edu

Darri Scalzo
Office of Research Compliance
686-8062
dlscalzo@uams.edu

Larry Cornett, Ph.D.
Office of the Vice Chancellor for Research
686-5347
cornettlawrencee@uams.edu

TRI Research and Career Development Seminar Slides Available

Slides are now available from Susan Steelman, MLIS, UAMS head of education and reference services, who was the Feb. 22 speaker for the TRI Research and Career Development Seminar Series.

Download: Library 301: Publishing Pitfalls & Resources for Researchers/Authors

The TRIbune Is Here!

The January-February TRIbune newsletter is here! This issue features some exciting developments in Big Data accessibility for UAMS researchers. We now offer researchers a new cohort tool and access to a larger data network. You’ll also read about Amhad Baghal, M.D., our first director of the Arkansas Clinical Data Repository (AR-CDR), formerly the UAMS Enterprise Data Warehouse. Baghal, who arrived in October, is continuing to build on the new opportunities now available, so stay tuned! TRI’s Beatrice Boateng, Ph.D., director of evaluation and continuous improvement, is the subject of our TRI & Me feature, and we include your TRI-cited publications.

Download PDF

Newsletter Archive

UAMS’ Data Sluice Machine

Biomedical informatics initiatives at UAMS cover the spectrum in the clinical and translational cycle for improving human health.

Biomedical informatics initiatives at UAMS cover the spectrum in the clinical and translational cycle for improving human health.

If new biomedical discoveries are like gold, to borrow the metaphor used by Meredith Zozus, Ph.D., the prospecting days are fast coming to an end. A new associate professor in the rapidly expanding Department of Biomedical Informatics (DBMI), Zozus was explaining UAMS’ recent and forthcoming biomedical informatics strategies to benefit clinicians, biomedical researchers and graduate students.

The need for managing enormous amounts of data and meeting the NIH’s new, higher expectations for rigor and study reproducibility are helping drive UAMS’ efforts for more robust data management systems. Another factor is the increasing difficulty compared to 20 years ago for a clinical researcher to make a single discovery that improves health outcomes, Zozus said.

“Back then, finding those gold nuggets was a lot easier. You could do a large study and learn something new that changed clinical practice and improved outcomes,” she said. “But those gold nuggets have become harder to find. So, like real-life prospectors, we’re moving from panning for gold to computationally sifting through tons of data to find the nuggets.”

Zozus also noted that the NIH, through its Big Data to Knowledge (BD2K) initiative, is targeting a growing shortage in biomedical research of individuals with computational expertise, informatics and statistics, with enough understanding of the underlying biology, biochemistry or physiology to really collaborate with a biomedical scientist. The challenge is particularly acute for extremely large datasets, where different methods are needed.

To help ensure UAMS is a leader in biomedical informatics, Fred Prior, Ph.D., who chairs DBMI and leads TRI’s Comprehensive Informatics Resource Center, recently announced new – some nationally unique – education initiatives to the TRI Leadership Council. Together the initiatives cover the translational spectrum, from molecules to populations. Pending approval from the Arkansas Department of Higher Education (ADHE), and starting in fall 2017, these four tracks in different areas of Biomedical Informatics will offer certificates, master’s degrees and doctorates:

Translational Bioinformatics. This degree program is for researchers using data in cellular and molecular level studies that have a clinical target, e.g., a study of genes producing a protein that has a role in disease. The field also encompasses work with pre-clinical data as development and testing begins for new targets, compounds or devices.

Imaging Informatics. Training in Imaging Informatics, offered only a few places nationally, includes coursework in research imaging to teach the latest modalities and methods of managing and interpreting images used in research. It also includes coursework for imaging professionals, i.e., those who run a hospital’s picture, archiving and communication (PAC) system where images such as CT scans, X-rays, and MRIs are stored.

Clinical Informatics. This program is for those interested in generation, management and use of information in health care settings, i.e., clinical decision support or algorithms to predict patients who are likely to respond well to treatment. Clinical informatics is a medical subspecialty approved in 2011 by the American Board of Medical Specialties. DBMI ran its first review course this summer to help physicians sitting for the clinical informatics board exam. The review class will be offered again this summer as a free service to all physicians in Arkansas who want to sit for the exam. Other plans include a fellowship in clinical informatics.

Clinical Research Informatics. If approved by ADHE, UAMS may be the first program to offer graduate degrees in Clinical Research Informatics in the United States.

Clinical research informatics involves data for the design, conduct and reporting of clinical studies. While easily confused with clinical informatics, clinical research informatics is not research on clinical informatics; instead, it is the informatics of research, i.e., how information is used in gauging the feasibility, or in designing, conducting or reporting clinical studies. If approved by ADHE this spring, the Clinical Research Informatics track will include a master’s degree and Ph.D. as well as a professional master’s option.

All four tracks will have the option of distance learning.

DBMI and TRI will also continue the Research & Application Seminar Series, which is open to the public and offers an hour of CME credit to clinical and informatics professionals across the state for attending seminars on the latest biomedical research tools and practices.

While biomedical informatics is not new to UAMS, it is increasingly approaching the data as a science, considering its fundamental properties and how those should govern its management, Zozus said.

“As an institution we are increasingly providing collaboration, informatics expertise and data infrastructure to biomedical researchers at all scales, from the smallest to the largest of studies, so our investigators don’t have to build their own data processes,” she said. “In essence, we are building a data sluice operation.”

UAMS Graduates 29 Certified Research Specialists

Twenty-nine UAMS research professionals received Certified Research Specialist (CRS) certificates at a graduation ceremony on Jan. 27. The graduation followed training that occurred in 2016.

The CRS program, managed by the Office of Research Compliance, requires that participants maintain Collaborative Institutional Training Initiative (CITI) Human Subjects Research training, complete 28 hours of relevant coursework, and pass a comprehensive proficiency exam. Graduates of the program earn the “CRS” credentials and maintain their certification status by completing six contact hours in applicable coursework in subsequent years.

The Translational Research Institute (TRI) requires its research staff to complete and maintain CRS certification, and other UAMS departments have also adopted CRS certification as a job requirement for certain research-related positions.

The 2016 Certified Research Specialist Graduates are:

  • Suzan Blair, College of Medicine (COM), Dermatology
  • Ashley Block, COM PEDS Birth Defects
  • Amanda Bull, COM Geriatrics
  • Pamela Christie, TRI Administration
  • Makethia Curtis, COM, Family and Preventive Medicine
  • Giuseppina Dusio, COM, Nephrology
  • Ashley Funderburg, College of Nursing, Geriatrics
  • Patricia Gminski , COM, Pathology
  • Susan Goolsby, Arkansas Children’s Hospital (ACH), Clinical Nutrition
  • Paul Griffiths, Myeloma Institute
  • Kathleen Hicks, COM, Pulmonary
  • Holly Jarrell, Myeloma Institute
  • Susannah Kirby, TRI Project Support Unit
  • Matthew Kovak , Cancer Clinical Trials
  • Teri Landrum, Nursing Services
  • Austin Lovenstein, ACH Nursing Research
  • Karen Mack, Nursing Services
  • Lisa McIntos, Office of Sponsored Programs Administrative Network
  • Heather Moody, OB/GYN Research
  • Veronica Overton, Psychiatric Research Institute

Entrepreneurship Series Begins Today, Expands to Other CTSA Institutions

amy-hester-data-warehouse

Amy Hester, Ph.D., R.N., will be the first presenter for this year’s Health Sciences Entrepreneurship Seminar Series.

The 2017 Health Sciences Entrepreneurship Seminar Series begins Feb. 1, with UAMS’ Amy Hester, Ph.D., R.N., director of Nursing Research and Innovation, speaking from 5 – 6 p.m. at the Reynolds Institute on Aging, Jo Ellen Ford Auditorium. 

Hester will present “Innovating in Healthcare: Idea Formation to Revenue Generation and Everything in Between.”

Hester’s research focuses on falls and injury prediction and prevention across the continuum of care. She is the inventor of multiple products and co-founded the biotechnology company HD Nursing, LLC in 2012, for which she is chief scientific officer. 

The UAMS Seminar Series this year is being offered in collaboration with the University of Alabama, Birmingham, University of Kansas Medical Center and the University of Utah – all Clinical and Translational Science Award (CTSA) institutions. The series is sponsored by the NIGMS Systems Pharmacology and Toxicology T32 Training Program, UAMS Translational Research Institute (TRI) and UAMS BioVentures.