Principal Investigator: Nishank Jain, M.D., associate professor, UAMS College of Medicine, Department of Internal Medicine, Division of Nephrology; TRI KL2 Mentored Research Career Development Program Scholar
Summary: An investigator-initiated study analyzing blood samples of adults with chronic kidney disease (CKD), adults with kidney transplants, and healthy adults to understand the interactions between platelets and leukocytes as possible drivers of inflammation in CKD.
Significance: CKD patients have abnormal inflammation associated with higher risks for heart attack and stroke. Having established that platelets are a primary cause, Jain hopes to identify the abnormal inflammatory pathways in CKD patients so that therapeutics may be found to inhibit platelets and reduce patients’ inflammatory burden.
TRI Services: ARresearch participant registry
Funding Agency: NIHNational Center for Advancing Translational Sciences
Learn more about the participant registry at TRI.uams.edu and ARresearch.org.