Current Scholars Bios

Cohort 9 (2019)

Tara Johnson, M.D.

Implementation and Quantification of the General Movement Assessment for Early Detection of Neurodevelopmental Disabilities in Infants
Tara JohnsonTara Johnson, M.D., is an assistant professor in the Department of Pediatrics/Division of Pediatric Neurology in the UAMS College of Medicine. She is the Founding Director of the Arkansas Children’s Biomedical Innovations Program. Prior to joining the Arkansas Children’s Research Institute and UAMS faculty in 2018, Dr. Johnson was at Kennedy Krieger Institute and the Johns Hopkins Hospital in Baltimore, MD, where she completed her training in Neurodevelopmental Disabilities. Dr. Johnson’s research work is focused on the early identification of infants at high risk for the development of cerebral palsy and other neurodevelopmental disorders.
Her KL2 Mentored Research Career Development Award project will transform current clinical practice at Arkansas Children’s Hospital by implementing the General Movement Assessment, a low-cost diagnostic tool, to identify Neurodevelopmental Disabilities at an earlier age in high-risk infants. By further enhancing qualitative assessments with quantitative engineering methods, she will advance the technical capability of the General Movement Assessment on a larger scale. She will transform the General Movement Assessment into a quantitative algorithm through her novel artificial-intelligence based analysis of the general movements in healthy and high-risk infants. This work will promote the initiation of proven therapies at a younger age, leading to improved outcomes in children with Neurodevelopmental Disabilities.
Successful completion of her work will bring novel approaches to the “bedside” for early identification and treatment of children with Neurodevelopmental Disabilities. She is poised to further develop her knowledge in engineering and clinical research to further benefit individuals from her translational study. Through her translational research, she will transform the standard of care for high-risk infants by incorporating the General Movement Assessment into day-to-day clinical care for these infants at Arkansas Children’s Hospital. The translational impact of the concurrent quantification of the general movements will outperform qualitative analyses and ultimately reach beyond ACH and can be adopted worldwide.

Mentors:

Alan Tackett, Ph.D., Scharlau Family Endowed Chair for Cancer Research; Associate Director for Basic Research, Winthrop P. Rockefeller Cancer Institute; Professor, Biochemistry and Molecular Biology, UAMS College of Medicine

Kenneth Knecht, M.D., Associate Professor, Pediatrics, UAMS College of Medicine

Gresham Richter, M.D., President, Physician Hospital Organization, Children’s Health Care System Inc.; Vice Chairman and Professor, Otolaryngology-Head and Neck Surgery, UAMS College of Medicine

Stefanie Kennon-McGill, Ph.D.

Project Title: Fetal exposure to cannabinoids: exposure, methylation, and neurodevelopmental effects

Kennon-McGillStefanie Kennon-McGill, Ph.D., is an instructor in the Department of Environmental and Occupational Health in the UAMS College of Public Health. The KL2 Mentored Research Career Development Award will support her efforts to evaluate the neurodevelopmental effects and epigenetic changes in children who were exposed to cannabinoids during the gestational period.
Cannabis and cannabis-derived phytochemicals known as cannabinoids, particularly the psychoactive component tetrahydrocannabinol (THC) and the non-psychoactive component cannabidiol (CBD), have become increasingly popular and widely available for use in the United States due to recent changes in state legislation. While there is a growing effort to evaluate the health effects of cannabinoids, especially during pregnancy, there is still relatively little known about the long term neurodevelopmental outcomes in children born to mothers who used any sort of cannabinoid during pregnancy.

Additionally, the mechanisms behind possible neurodevelopmental changes in children exposed to cannabis prenatally have not been thoroughly explored, particularly in humans. It has been suggested that epigenetic modifications may play an important role in “reprogramming” the developing fetal brain following prenatal exposure to cannabis. Yet, few studies have evaluated this quantitatively in humans. Dr. Kennon-McGill aims to fill these gaps in knowledge by using state-of-the-art analytical methods to quantify THC, CBD, and metabolites in mother/infant pairs where mother reports use of THC or CBD in the final trimester of pregnancy. Her study will also entail neurodevelopmental assessments in the infants at 6 and 12 months of age. The role of DNA methylation as a possible mechanism of importance in neural development will be examined as well.

Dr. Kennon-McGill joined the UAMS College of Public Health in 2017. Prior to her time at UAMS, she received her doctorate in Neuroscience from the University of Kansas Medical Center in 2014 and then completed a two year postdoctoral fellowship at Washington University in St. Louis.

Mentors:
Laura James, M.D., Associate Vice Chancellor, Clinical and Translational Research; Professor, Department of Pediatrics; Director, Translational Research Institute, UAMS College of Medicine

Shuk-Mei Ho, Ph.D., Vice Chancellor of Research; Professor, Department of Pharmacology and Toxicology, UAMS College of Medicine

John Constantino, M.D., Director of the Division of Child and Adolescent Psychiatry; Blanche F. Ittleson Professor of Psychiatry and Pediatrics Washington University, Saint Louis, MO

Ricky Leung, Ph.D., Associate Professor, Department of Pharmacology and Toxicology, UAMS College of Medicine

Jeff Moran, Ph.D., Assistant Professor, Department of Pharmacology and Toxicology, UAMS College of Medicine

Pearman Parker, Ph.D., M.P.H., RN

Project Title:An Exploration of the Mental Health Needs of Young Women with Breast Cancer and Implications for Developing Patient Educational Materials

Pearman Parker Pearman Parker, Ph.D., M.P.H., RN, is a clinical instructor in the College of Nursing. The KL2 Mentored Research Career Development Award will support her project examining perceived mental health needs of young women with breast cancer. This project will also explore the mental health content within breast cancer educational materials.

Young women (18 – 45 years of age) with breast cancer are especially vulnerable to overwhelming daily stressors of cancer and face unique mental health challenges. However, due to the urgency of undergoing treatment and managing physiological side effects, mental health needs such as depression and anxiety are often not a priority. Younger women with breast cancer often have to learn about their disease and ways to cope with mental health at convenient times amidst the competing demands of treatment, family, and work responsibilities. They frequently rely on easily accessible cancer education materials to accommodate daily life schedules. However, we do not know the extent to which cancer education materials address mental health needs of this population, nor if the mental health content that does exist is readable and understandable for patients with a variety of health literacy skill levels. The purpose of this study is to explore the perceived mental health needs and the mental health content within cancer educational materials for young women with breast cancer. This study will provide the foundation for this program of research, which is dedicated to developing tailored educational interventions to improve the breast cancer treatment experience.

Dr. Parker joined the College of Nursing as a new faculty member in 2019. She received her doctorate from the University of South Carolina where her dissertation was funded through the Susan G. Komen Foundation. Dr. Parker draws upon her years as a psychiatric nurse and journalist to inform her evolving research.

Mentors:

Jean McSweeney, Ph.D., RN, FAAN, FAHA, Associate Dean for Research; Professor, UAMS College of Nursing

Kristin Zorn, MD, Professor, Department of Obstetrics and Gynecology; Associate Professor, Genetics, UAMS College of Medicine

Joseph Su, PhD, Co-Director, Cancer Prevention and Population Sciences, UAMS Winthrop P. Rockefeller Cancer Center; Professor, Department of Epidemiology, UAMS College of Public Health

Kristie Hadden, PhD, Executive Director, UAMS Center for Health Literacy; Associate Professor, Department of Medical Humanities and Bioethics, UAMS College of Medicine.

Carolyn Greene, PhD, National Program Manager, Office of Mental Health and Suicide Prevention, Washington DC; Associate Professor, Health Services Research Division, UAMS Department of Psychiatry

Isabelle Racine-Miousse, Ph.D.

Project Title: Decreasing methionine intake to improve survival in patients with metastatic melanoma

Isabella Racine Miousse Isabelle Racine Miousse, Ph.D., is an Assistant Professor in the Department of Biochemistry and Molecular Biology in the UAMS College of Medicine. The KL2 Mentored Research Career Development Award will support her research in improving survival in patients with metastatic melanoma by exploiting a metabolic vulnerability in cancer cells.
In healthy animals, a reduction in methionine dietary intake leads to significant gains in metabolic health and an increase in lifespan. In contrast, most cancer cells are strictly dependent on the supply of exogenous methionine for survival, a phenomenon called “methionine dependence”. Based on this dichotomy, her project explores a window of methionine intake where we observe health benefits and preservation of body weight for the host, while at the same time impairing proliferation and metastasis in tumor. The three axes of the project are to link common genetic variations in methionine metabolism with the outcome of cancer therapy, to identify the molecular mechanism behind methionine dependence in cancer cells, and finally, to combine dietary methionine restriction with immunotherapy in metastatic melanoma. The long term objectives of this research is to increase the response rate to therapy with immune checkpoint inhibitors in metastatic melanoma, which currently stands at 50%, while at the same time improving quality of life in patients during the course of treatment.
Miousse joined the College of Medicine faculty in 2018 after completing her postdoctoral fellowship at UAMS. She received her doctorate in Human Genetics from McGill University in Montreal, Canada.

Mentors:
Alan Tackett, Ph.D., Scharlau Family Endowed Chair for Cancer Research; Associate Director for Basic Research, Winthrop P. Rockefeller Cancer Institute; Professor, Biochemistry and Molecular Biology, UAMS College of Medicine

Issam Makhoul, M.D., Director, Division of Hematology Oncology; Professor, Internal Medicine, UAMS College of Medicine

Laura F. Hutchins, M.D., Endowed Chair for Hematology and Oncology, Professor, Internal Medicine, UAMS College of Medicine

Jennifer Vincenzo, Ph.D., M.P.H, PT

Development of a Falls Prevention Self-Management Plan to Improve Older Adults Adherence to Prevention Strategies after Community-Based Falls Risk Screenings

Jennifer Vincenzo Jennifer Vincenzo, Ph.D., M.P.H., PT, is an assistant professor in the Lewis E. Epley Jr. Department of Physical Therapy in the College of Health Professions on the Northwest Campus. The KL2 Mentored Research Career Development Award will support her project to develop and pilot a falls prevention self-management plan to facilitate adherence to prevention strategies among older adults.
Falls are the leading cause of fatal and nonfatal injuries among older adults, costing upwards of $50 billion every year. Despite national efforts towards prevention, fall rates remain high. One in four older adults falls each year nationally and Arkansas ranks 48/50 with fall rates of 35.2%. The CDC provides falls prevention screening, assessment, and recommendation resources; however, there are no resources in place to assist providers and older adults in developing and implementing a falls prevention self-management plan.
Developing strategies to improve adherence to fall prevention recommendations is imperative to addressing this public health crisis. Results from Dr. Vincenzo’s preliminary studies indicate only ~50% of older adults adhere to recommendations following a one-time community-based falls prevention screening. Moreover, she found that those who were not adherent reported higher rates of falls compared to those who were. Thus, implementing a falls prevention self-management plan could prevent up to 45,000 medically treated falls, save $442 million in direct medical costs associated with those falls, and decrease the risk of falls by up to 67%.
Barriers and facilitators to adhering to falls prevention recommendations have been identified; however, implementation strategies to address older adults’ lack of adherence have not been explored. Therefore, the aims of this project are to develop and pilot a falls prevention self-management plan to improve older adults’ adherence to falls prevention recommendations after attending a community-based screening.
Vincenzo joined the Department of Physical Therapy in 2015. She completed her Ph.D. in Kinesiology with a graduate certificate in Educational Statistics and Research Design at the University of Arkansas. She also has a Master of Public Health from Southern Connecticut State University and a Bachelor of Physical Therapy degree from Quinnipiac College in Hamden, Connecticut. Vincenzo was an inaugural recipient of the UAMS Geriatric Junior Faculty Development Award through the Arkansas Geriatric Education Collaborative. She holds board certifications in Geriatric Physical Therapy, Health Education, Brain Injury Rehabilitation, and Dementia Management.

Mentors:

Jeanne Wei, Ph.D, M.D., Executive Director, Reynolds Institute on Again, UAMS; Chair, Geriatrics, UAMS College of Medicine.

Leanne Lefler, Ph.D, R.N, A.P.R.N., Associate Professor, UAMS College of Nursing

Pearl McElfish, Ph.D., Vice Chancellor Northwest Arkansas region, UAMS; Assistant Professor, Office of Community Health and Research, UAMS College of Medicine

Geoffrey Curran, Ph.D., Director, Center for Implementation Research; Professor, Department of Pharmacy Practice, UAMS College of Pharmacy

Cohort 8 (2017)

Lisa Brents, Ph.D.

Project Title: The Metabolic and Pharmacodynamic Profile of Deuterated Buprenorphine

Lisa Brents, Ph.D.Lisa Brents, Ph.D., is an instructor in the Department of Pharmacology and Toxicology in the UAMS College of Medicine. The KL2 Mentored Research Career Development Award will support her project that attempts to improve buprenorphine treatment of opioid use disorder during pregnancy by reducing fetal exposure to an active metabolite of buprenorphine, norbuprenorphine.

Opioid abuse during pregnancy often leads to withdrawal in the neonate, which can be painful and difficult to treat and requires prolonged, costly care in neonatal intensive care units. Buprenorphine is a highly effective treatment for pregnant women who have opioid use disorder and considerably improves maternal and neonatal outcomes; however, because buprenorphine is an opioid, it too can cause neonatal withdrawal symptoms. Several lines of evidence suggest that fetuses of buprenorphine-treated women are exposed to significant amounts of norbuprenorphine, an active metabolite of buprenorphine that is a powerful opioid and can contribute to fetal opioid dependence that leads to neonatal opioid withdrawal. This project will use in vitro and rodent models to test a modified version of buprenorphine that is expected will resist metabolism to norbuprenorphine but will otherwise retain the pharmacological properties of buprenorphine. It is anticipated that this modification will successfully treat maternal opioid use disorder while reducing fetal exposure to norbuprenorphine and neonatal withdrawal severity.

Brents joined the UAMS College of Medicine faculty in 2016 and was an inaugural recipient of the UAMS Fellow-to-Faculty Award. She was a National Institute on Drug Abuse (NIDA) T32 postdoctoral fellow in the Brain Imaging Research Center with the UAMS Department of Psychiatry. Brents completed her doctoral dissertation in 2013 in the Department of Pharmacology and Toxicology in the UAMS College of Medicine.

Mentors:

Anna Radominska-Pandya, Ph.D., Professor, Department of Biochemistry and Molecular Biology, UAMS College of Medicine

Jeffery Moran, Ph.D., Assistant Professor, Department of Pharmacology and Toxicology, UAMS College of Medicine; Branch Chief, Division of Environmental Chemistry

Michael Owens, Ph.D., Professor, Wilbur Mills Endowed Chair in Alcohol and Drug Abuse Prevention, Department of Pharmacology and Toxicology, UAMS College of Medicine


Rosemary Nabaweesi, Dr.P.H.

Project Title: Developing Safe Sleep Interventions for Rural Underserved Communities

Rosemary Nabaweesi, Dr.P.H.Rosemary Nabaweesi, Dr.P.H., is an assistant professor in the Department of Pediatrics, in the UAMS College of Medicine.

Nabaweesi‘s research work is focused on injury-related infant mortality prevention and reduction of health disparities for rural and underserved populations. Specifically, her research seeks to help rural minority communities achieve better health status for their children by using applied research tools to develop creative solutions, which reduce infant mortality due to SIDS and unsafe sleep practices. Her KL2 Mentored Research Career Development Award project uses an implementation approach to: 1) explore barriers and facilitators to safe sleep adherence and 2) adapt a safety baby shower as a safe sleep intervention and to identify implementation support strategies using an evidence-based quality improvement process.

Barriers associated with knowledge, attitudes, and behavior hinder parental adherence to safe sleep recommendations especially among minority populations in rural underserved communities. Nabaweesi’s KL2 project is the first study engaging community advisors in a needs assessment to inform a safe sleep intervention adaptation.

Successful completion of her work will lead to an enhanced safe sleep intervention (SSI); with appropriate implementation strategies, which once tested for feasibility and clinical effectiveness will promote increased safe sleep messaging uptake, fidelity, and sustainability in rural underserved communities. An adapted and pilot tested SSI may potentially reduce infant mortality by keeping infants safe during sleep and contribute to future reduction of Sudden Unexpected Infant Death (SUID), which includes Sudden Infant Death (SIDS), and health disparities.

Prior to joining the Arkansas Children’s Research Institute and UAMS faculty in 2014 as a health services researcher at the Center for Applied Research and Evaluation (CARE), Nabaweesi was at Johns Hopkins Bloomberg Children’s Center. She also has an adjunct appointment with the Department of Health Policy and Management in the UAMS Fay W. Boozman College of Public Health.

Mentors:

Mary Aitken, M.D., M.P.H., Professor, Department of Pediatrics, College of Medicine, Co-Director, TRI KL2 Scholar Program

Geoffrey Curran, Ph.D., Director, Center for Implementation Research; Professor, Department of Pharmacy Practice, College of Pharmacy, and Department of Psychiatry, College of Medicine

Keneshia Bryant-Moore, Ph.D., R.N., F.N.P.-B.C., Associate Professor, Department of Health Behavior and Health Education, College of Public Health


Carolina Schinke, M.D.

Project Title: The Role of Pl-IF 19 as a Promoter of Tumorigenicity and Therapeutic Target in Multiple Myeloma

Carolina Schinke, M.D.Carolina Schinke, M.D., is an assistant professor in the Department of Internal Medicine in the UAMS College of Medicine and is based at the Myeloma Institute. The KL2 Mentored Research Career Development Award will support her research in determining yet undiscovered pathologic pathways in multiple myeloma and identifying new therapeutic targets.

Multiple Myeloma is a hematopoietic malignancy of differentiated plasma cells that reside within the bone marrow. It is the second most common hematologic cancer that remains incurable in the majority of patients with a low rate of survival and a need for development of new treatments. The disease course is typically characterized by recurrent relapses and increasing drug resistance that will eventually lead to aggressive disease proliferation and patient death. Preliminary work has identified PHD finger protein 19 (PHF19) as a promoter of tumor growth, drug resistance and a marker of poor prognosis in multiple myeloma. PHF19 is the main regulator of a pathway known to cause transcriptional repression and genetic silencing through histone methylation at the DNA level. It is thought that this genetic repression leads to under-expression of tumor suppressor genes resulting in a more aggressive disease phenotype.

The current project will provide functional and mechanistic data on PHF19 as a disease promoter in multiple myeloma. It is anticipated that uncovering the molecular mechanisms by which PHF19 regulates multiple myeloma will determine yet unknown pathologic pathways that will lead to the discovery of new therapeutic targets and treatment interventions.

Schinke joined the Myeloma Institute in 2014 after completing her medical residency and hematology-oncology fellowship at the Albert Einstein College of Medicine in the Bronx, NY. She received her medical degree from the University of Halle-Saale, Germany and is certified by the American Board of Internal Medicine in the subspecialties of Hematology and Medical Oncology.

Mentors:

Brian Walker, Ph.D., Professor, Department of Internal Medicine, College of Medicine, Director of Research, UAMS Myeloma Institute

Frits van Rhee, M.D., Ph.D. Professor, Department of Internal Medicine, College of Medicine, Director of Developmental and Translational Medicine, UAMS Myeloma Institute

Amit Verma, M.D., Professor, Department of Medicine and Department of Molecular Biology, Albert Einstein College of Medicine, Bronx, N.Y.


Sufna John, Ph.D.

Project Title: Improving Outcomes for Young Children with Behavior Disorders: A Coordinated Care Model

Sufna John, Ph.D.Sufna John, Ph.D., is an assistant professor in the Department of Psychiatry/Division of Psychology in the UAMS College of Medicine. The KL2 Mentored Research Career Development Award will support her project examining the impact of early childhood education factors on the effectiveness of therapy services for preschool-aged children who present with disruptive behaviors. This project will also pilot a coordinated care model to enhance outcomes for young children and families who receive services across settings.

Behavior disorders are the second most common mental health condition in youth, with up to 20% of children nationally meeting full criteria for diagnosis. Behavioral difficulties during early childhood predict high-risk behaviors during adolescence (e.g., substance abuse) and severely problematic outcomes in adulthood (e.g., criminality). These behaviors tend to persist without effective treatment, thus representing a significant public health concern. Fortunately, several evidence-based treatments (EBTs) exist for young children who exhibit these difficulties (e.g., Parent-Child Interaction Therapy – PCIT). Given that disruptive behaviors manifest across settings, children are often targeted for both clinic-based and childcare-based services. However, no research to date has examined the compatibility between or impact of receiving both services across settings. Anecdotally, parents and teachers frequently report utilizing conflicting behavior-management strategies, thus giving children inconsistent opportunities to improve their behavior. The goal of my study is to improve the trajectory of young children with disruptive behaviors through enhancing the compatibility and coordination of the services they receive.

John joined the College of Medicine faculty in 2015 after completing both her pre-doctoral internship and postdoctoral fellowship at UAMS. She received her doctorate in Child Clinical Psychology from Southern Illinois University in Carbondale, Illinois. She is a nationally-certified clinician in several EBTs for infants, toddlers and preschoolers (including PCIT).

Mentors:

Teresa Kramer, Ph.D., Professor and Chief Psychologist, Department of Psychiatry, UAMS College of Medicine

Nicola Conners Edge, Ph.D., Associate Professor, Department of Family and Preventive Medicine, UAMS College of Medicine

Nicholas Long, M.D., Professor, Department of Pediatrics, UAMS College of Medicine

Michael Anthony Cucciare, Ph.D., Assistant Professor, Department of Psychiatry, UAMS College of Medicine